Hyaluronidase (human recombinant)
Hyaluronidase (human recombinant) is an enzyme pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| darzalex faspro | Biologic Licensing Application | 2023-11-28 |
| herceptin hylecta | Biologic Licensing Application | 2019-05-13 |
| hylenex recombinant | Biologic Licensing Application | 2024-01-24 |
| phesgo | Biologic Licensing Application | 2020-06-29 |
| vyvgart hytrulo | Biologic Licensing Application | 2023-12-15 |
Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
175 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | — | — | 2 | — | 18 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 3 | 3 | — | 3 | — | 9 |
| Primary immunodeficiency diseases | D000081207 | — | — | 1 | 2 | 4 | 1 | 3 | 9 |
| Dehydration | D003681 | — | E86.0 | 1 | 1 | — | 6 | 1 | 9 |
| Cardiac output | D002302 | — | — | — | — | — | 1 | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 9 | 5 | 4 | — | — | 16 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 4 | 5 | — | — | 11 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 2 | 2 | — | — | 6 |
| Melanoma | D008545 | — | — | — | 3 | 2 | — | — | 5 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | 1 | 1 | — | — | 3 |
| B-cell lymphoma | D016393 | — | — | 1 | — | 1 | — | — | 2 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | D020277 | EFO_1000868 | G61.81 | — | — | 2 | — | — | 2 |
| Pemphigus | D010392 | EFO_1000749 | L10 | — | — | 2 | — | — | 2 |
| Bullous pemphigoid | D010391 | EFO_0007187 | L12 | — | 1 | 2 | — | — | 2 |
| Myositis | D009220 | EFO_0000783 | G72.49 | — | 1 | 2 | — | — | 2 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 5 | 6 | — | — | — | 9 |
| Neoplasms | D009369 | — | C80 | 8 | 3 | — | — | — | 8 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 1 | — | — | — | 4 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 1 | — | — | — | 3 |
| Follicular lymphoma | D008224 | — | C82 | 2 | 2 | — | — | — | 3 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 2 | 1 | — | — | — | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | — | 2 | — | — | — | 2 |
| Hereditary angioedemas | D054179 | EFO_0004131 | — | — | 2 | — | — | — | 2 |
Show 15 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 2 | — | — | — | — | 2 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | 1 | — | — | — | — | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 2 | 2 |
| Stiff-person syndrome | D016750 | EFO_0007498 | G25.82 | — | — | — | — | 1 | 1 |
| Invasive hydatidiform mole | D002820 | — | D39.2 | — | — | — | — | 1 | 1 |
| Pain management | D059408 | — | — | — | — | — | — | 1 | 1 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Hyaluronidase (human recombinant) |
| INN | vorhyaluronidase alfa |
| Description | Hyaluronidase (human recombinant) is an enzyme pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Enzyme |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201718 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 743QUY4VD8 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,298 documents
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Safety
Black-box Warning
Black-box warning for: Herceptin hylecta, Phesgo
Adverse Events
Top Adverse Reactions
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5,171 adverse events reported
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